Jointly provided by Partners for Advancing Clinical Education (PACE) and PlatformQ Health Education, LLC.

ACKNOWLEDGEMENT

This activity is supported by independent medical educational grants from Astellas and Merck.

DATE OF RELEASE/EXPIRATION

This activity was released on November 9, 2023 and is valid until November 9, 2024. Requests for credit must be made no later than November 9, 2024.

TARGET AUDIENCE

The primary target audience for this activity are medical oncologists, GI oncologists, gastroenterologists, oncology nurses, nurse practitioners, physician assistants, oncology pharmacists, and other clinicians involved in the management of patients with gastric or GEJ cancer.

STATEMENT OF NEED/PROGRAM OVERVIEW

Gastric and gastroesophageal junction (GEJ) cancers are difficult to treat and have poor prognosis, particularly for patients who do not carry HER2 alterations. Recent advances in targeted therapy and immunotherapy for HER2-negative advanced gastric and GEJ cancers are changing the treatment landscape for these difficult-to-treat cancers, providing new treatment options and improving patient outcomes.

Join a panel of two gastrointestinal oncologists to discuss novel biomarkers that can guide treatment of HER2-negative gastric cancer, factors that can influence therapy selection for patients, and strategies to maximize outcomes by managing treatment-associated adverse events.

EDUCATIONAL OBJECTIVES

After completing this activity, the participant should be better able to:

• Discuss biomarker testing and its significance in selecting therapy to manage patients with gastric and GEJ cancers
• Evaluate efficacy and safety data from practice-changing clinical trials on new and emerging targeted therapies for HER2-negative metastatic gastric and GEJ cancers
• Discuss optimum management of MSI-H/dMMR tumors with immune checkpoint inhibitors (ICIs)
• Outline adverse events associated with targeted therapies and immunotherapies for HER2-negative metastatic gastric and GEJ cancers

JOINT ACCREDITATION STATEMENT

In support of improving patient care, this activity has been planned and implemented by Partners for Advancing Clinical Education (PACE) and PlatformQ Health Education, LLC. PACE is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

PHYSICIAN CONTINUING EDUCATION

PACE designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ESTIMATED TIME TO COMPLETE

This activity should take approximately 60 minutes to complete.

INSTRUCTIONS TO RECEIVE CREDIT

In order to receive credit for this activity, the participant must (1) read the target audience, learning objectives, and disclosure statements, (2) complete the educational activity online, and (3) complete the post-test and activity evaluation. To receive AMA PRA Category 1 Credits™, participants must receive a score of 75% on the post-test.

HARDWARE/SOFTWARE REQUIREMENTS

Participants will need a computer with a recent version of Adobe Flash installed, as well as an internet connection sufficient for streaming media.

FEE INFORMATION & REFUND/CANCELLATION POLICY

There is no fee for this educational activity.

FACULTY AND DISCLOSURE OF CONFLICTS OF INTEREST

PACE requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial relationships they may have with ineligible companies. All relevant financial relationships are thoroughly vetted and mitigated according to PACE policy. PACE is committed to providing learners with high-quality accredited CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Faculty	Conflicts of Interest
Manish A. Shah, MD, FASCO Chief, Solid Tumor Oncology Service Director, Gastrointestinal Oncology Program Co-Director, Center for Advanced Digestive Care Bartlett Family Professor of Gastrointestinal Oncology Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine	Research Grant: Astellas, Bristol Meyers Squibb, Merck
Zev Wainberg, MD Professor of Medicine and Surgery Co-Director, GI Oncology Program Director, Early Phase Clinical Research Program Jonsson Comprehensive Cancer Center UCLA School of Medicine	Consultant, Advisor: Amgen, Arcus, Astellas, Astra Zeneca, Bayer, Bristol Meyers Squibb, Daiichi, Gilead, Ipsen, Merck, Novartis, Seagen Grant: Arcus, Bristol Meyers Squibb

The PACE planners and others have no relevant financial relationship(s) to disclose with ineligible companies. The PlatformQ Health Education, LLC planners and others have no relevant financial relationship(s) to disclose with ineligible companies.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

DISCLAIMER:

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

CONTACT INFORMATION

Accreditation Support:

For additional information about the accreditation of this activity, please visit https://partnersed.com.

Technical Support:

For any technical issues or issues with your CME Certificate, please contact OMedLive at 877-394-1306 or at Support@OMedLive.com.