CME Presentations




  • Satheesh Chonat, MD

    Satheesh Chonat, MD

    Satheesh Chonat, MD

    Assistant Professor, Pediatric Hematology

    Satheesh Chonat, MD, is a board-certified Pediatric Hematologist/Oncologist at Children’s Healthcare of Atlanta and an Assistant Professor of Pediatrics at Emory University School of Medicine. Dr. Chonat specializes in the care of children and young adults with nonmalignant rare blood disorders and has a research focus on rare anemias and complement disorders. He is particularly interested in leveraging pre-clinical animal models and translational research to explore the mechanisms underlying hemolytic anemias and thrombotic microangiopathies, investigate biomarkers for diagnostic testing, and develop newer therapies. Dr. Chonat is also the site investigator for various clinical and translational research projects, focused on rare red blood disorders, such as pyruvate kinase disease.
  • Carlos de Castro, MD

    Carlos de Castro, MD

    Carlos de Castro, MD

    Professor of Medicine, Division of Hematologic Malignancies & Cell Therapy

    Carlos de Castro, MD, is a Professor of Medicine at Duke University in the Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine and a member of the Duke Cancer Institute. His clinical research focuses on treatments for bone marrow failure conditions such as paroxysmal nocturnal hemoglobinuria (PNH), aplastic anemia, myelodysplastic syndromes, and acute leukemias. Dr. de Castro has served in several roles at Duke including Medical Director of the 9100 Malignant Hematology Ward, Medical Director of the Apheresis Unit, and Program Director of the Duke Hematology-Oncology Fellowship Program. He is on the NCCN panel for Myelodysplastic Disorders and serves as a member of the Medical Board of Directors for the Aplastic Anemia & MDS International Foundation.

CME Information

Global Logo PQH Logo
Complement Regulation and Unmet Needs in the Treatment of Paroxysmal Nocturnal Hemoglobinuria
This activity is jointly provided by Global Education Group and PlatformQ Health Education, LLC, in collaboration with the Aplastic Anemia and MDS International Foundation (AAMDS), and National Organization for Rare Disorders (NORD)


This activity is supported by an educational grant from Apellis Pharmaceuticals Inc.


This activity was released on May 26, 2022 and is valid until May 26, 2023. Requests for credit must be made no later than May 26, 2023.


The target audiences for the proposed HCP activity are Community-based and academic hematologists, medical oncologists, hematologic oncologists, pathologists, primary care providers, nurses and nurse navigators, nurse practitioners, physician assistants, and pharmacists.


Quality of life for patients with the rare blood disorder paroxysmal nocturnal hemoglobinuria (PNH) could be greatly improved with faster diagnoses, appropriate treatments, and management of a plethora of challenges that persist despite therapy. A low index of suspicion for PNH and a lack of familiarity with diagnostic criteria often lead to lengthy delays in diagnoses and a lack of treatment for patients. In addition, recent advances in therapeutic options and issues of convenience related to complement-regulating therapies for PNH make it difficult to select the most appropriate treatment for each patient.

Join hematology experts Dr. Carlos de Castro and Dr. Satheesh Chonat to explore strategies to identify and diagnose PNH earlier in the disease course. Patient case studies will help clinicians select the most appropriate treatment for complement regulation and address the significant health burdens and disease complications experienced by many patients during treatment. In addition, panelists will discuss special patient circumstances that may require additional counseling or guidance to available resources.


After completing this activity, the participant should be better able to:
  • Describe strategies to decrease delays in the diagnosis of PNH
  • Review existing and emerging therapeutic agents for PNH that target the complement cascade
  • Discuss management of persistent challenges experienced by patients with PNH that impact quality of life
  • Identify special circumstances that require counseling of patients with PNH


This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Global Education Group (Global) and PlatformQ Health Education, LLC. Global is accredited by the ACCME to provide continuing medical education for physicians.


Global Education Group designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


This activity should take approximately 90 minutes to complete.


In order to receive credit for this activity, the participant must (1) read the target audience, learning objectives, and disclosure statements, (2) complete the educational activity online, and (3) complete the post-test and activity evaluation. To receive AMA PRA Category 1 Credits™, participants must receive a minimum score of 100% on the post-test.


Participants will need a computer with a recent version of Adobe Flash installed, as well as an internet connection sufficient for streaming media.


There is no fee for this educational activity.


Global Education Group (Global) adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global. All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias.

All relevant financial relationships have been mitigated.

The faculty have the following relevant financial relationships with ineligible companies:

Name of Faculty or Presenter Reported Financial Relationship
Dr. Satheesh Chonat, M.D
Assistant Professor, Pediatric Hematology
Emory University School of Medicine
Children’s Healthcare of Atlanta
Consulting Fee (e.g., Advisory Board): Agios, Alexion, Daichi Sankyo, Forma Therapeutics, Novartis, and Takeda pharmaceuticals
Contracted Research: Agios, Alexion, Amgen, Apellis, Global Blood Therapeutics, Takeda
Dr. Carlos de Castro
Professor of Medicine
Department of Medicine, Division of Hematologic Malignancies & Cell Therapy
Duke University
Consulting Fee (e.g., Advisory Board): Alexion Pharmaceuticals,Apellis Pharmaceuticals, Biocryst Pharmaceuticals, Novartis Pharmaceuticals
Speakers Bureau: Apellis Pharmaceuticals
Other: Regeneron Pharmaceuticals (Data Safety Monitoring Committee)

The planners and managers have the following relevant financial relationships with ineligible companies:

Name of Planner or Manager Reported Financial Relationship
Lindsay Borvansky Nothing to disclose
Andrea Funk Nothing to disclose
Liddy Knight Nothing to disclose
Ashley Cann Nothing to disclose
Sumera Ackbarali Nothing to disclose
Caroline Laurendeau Nothing to disclose
Theresa Elgin-Patient Participant Nothing to disclose


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) and PlatformQ Health Education, LLC do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Accreditation Support: For information about the accreditation of this program, please contact Global at 303-395-1782 or

Technical Support: For any technical issues or issues with your CME Certificate, please contact OMedLive at 877-394-1306 or at