Jointly provided by Partners for Advancing Clinical Education (PACE) and PlatformQ Health Education, LLC.

ACKNOWLEDGEMENT

This program has been supported by an independent educational grant from Gilead Sciences, Inc.

DATE OF RELEASE/EXPIRATION

Thursday, April 6, 2023 from 12:30-1:30pm ET.

TARGET AUDIENCE

The educational design of this activity addresses the needs of hematologic oncologists, hematologists, medical oncologists, oncology advanced practice providers (NPs and PAs), oncology nurses, pharmacists, and other clinicians involved in the management of patients with myelodysplastic syndrome (MDS).

STATEMENT OF NEED/PROGRAM OVERVIEW

While approved chemotherapies and allogeneic stem-cell transplant have shown some success in the treatment of myelodysplastic syndrome (MDS), patients can still relapse or become refractory to treatment. Based on their risk stratification, patients with MDS need to receive the most suitable and effective therapy upfront. Clinical trials on immunotherapies for MDS are ongoing and agents with novel mechanisms are showing promising results.

Join a panel of expert hematologists and oncologists to review the team- and system-based gaps that prevent timely integration of new therapies for MDS. Panelists will share strategies to overcome barriers to the use of new advances in care and to create personalized treatment plans for patients with high-risk MDS based on their needs and preferences. Clinicians will learn how to select the right patients for novel therapies, whether through participation in clinical trials or in preparation of anticipated approvals.

EDUCATIONAL OBJECTIVES

After completing this activity, the participant should be better able to:

• Discuss the rationale for and mechanisms of action of novel immunotherapies for high-risk MDS
• Evaluate efficacy and safety profiles of emerging immunotherapies for high-risk MDS
• Outline strategies to individualize treatment plans for patients with high-risk MDS and align care with clinical guidelines

JOINT ACCREDITATION STATEMENT

PHYSICIAN CONTINUING EDUCATION

PACE designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ESTIMATED TIME TO COMPLETE

This activity should take approximately 60 minutes to complete.

INSTRUCTIONS TO RECEIVE CREDIT

In order to receive credit for this activity, the participant must (1) read the target audience, learning objectives, and disclosure statements, (2) complete the educational activity online, and (3) complete the post-test and activity evaluation. To receive AMA PRA Category 1 Credits™, participants must receive a score of 75% on the post-test.

HARDWARE/SOFTWARE REQUIREMENTS

Participants will need a computer with a recent version of Adobe Flash installed, as well as an internet connection sufficient for streaming media.

FEE INFORMATION & REFUND/CANCELLATION POLICY

There is no fee for this educational activity.

FACULTY AND DISCLOSURE OF CONFLICTS OF INTEREST

PACE requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial relationships they may have with ineligible companies. All relevant financial relationships are thoroughly vetted and mitigated according to PACE policy. PACE is committed to providing learners with high-quality accredited CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company. The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Name of Faculty or Presenter	Reported Financial Relationship
Naval Daver, MD Associate Professor Director, Leukemia Research Alliance Program Department of Leukemia MD Anderson Cancer Center	Consultant, Advisor, Speaker: AbbVie; Agios; Amgen; Arog; Astellas; Bristol-Meyers Squibb; Celgene; Daichii-Sankyo; Gilead; ImmunoGen; Jazz; Novartis; Pfizer; Servier; Servier; Shattuck Labs; Syndax; and Trillium. Executive Role: Hanmi Pharmaceutical Researcher: AbbVie; Amgen; Astellas; Bristol-Meyers Squibb; Daichii-Sankyo; FATE Therapeutics; Genentech; Gilead; Glycomimetics; ImmunoGen; Novimmune; Pfizer; Servier; Trillium; and Trovagene.
David Sallman, MD Assistant Member Myeloid Malignancies Section Head, Malignant Hematology Moffitt Cancer Center	Consultant, Advisor, Speaker: AbbVie; Affimed Gmbh; Avencell; Bluebird Bio; Bristol Myers Squibb; Gilead; Incyte; Intellia; Intellisphere, LLC; Jasper Therapeutics; Kite; Molecular Partners AG; Novartis; PGEN Therapeutics, Inc.; Servier; Shattack Labs; Syndax; Takeda; and Zentails. Researcher: Aprea and Jazz

The PACE planners and others have no relevant financial relationship(s) to disclose with ineligible companies. The PlatformQ Health Education, LLC planners and others have no relevant financial relationship(s) to disclose with ineligible companies.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

DISCLAIMER

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

CONTACT INFORMATION

Accreditation Support:

For additional information about the accreditation of this activity, please visit https://partnersed.com.

Technical Support:

For any technical issues or issues with your CME Certificate, please contact OMedLive at 877-394-1306 or at Support@OMedLive.com.

This activity is jointly provided by Global Education Group and PlatformQ Health Education, LLC, in collaboration with the Aplastic Anemia and MDS International Foundation (AAMDSIF).

ACKNOWLEDGEMENT

This activity is supported by an educational grant from Gilead Sciences, Inc.

DATE OF RELEASE/EXPIRATION

This activity was released on June 3, 2022 and is valid for 12 months. Requests for credit must be made no later than June 3, 2023.

TARGET AUDIENCE

The educational design of this activity addresses the needs of hematologic oncologists, hematologists, medical oncologists, BMT specialists, NPs, PAs, oncology nurses, and other clinicians involved in the management of patients with MDS.

STATEMENT OF NEED/PROGRAM OVERVIEW

While current therapies are inadequate for many patients with myelodysplastic syndromes (MDS), emerging therapies with different mechanisms of action are poised to provide more treatment options for newly diagnosed MDS and allow clinicians to treat with more certainty.

Join Dr. Naval Daver and Dr. Guillermo Garcia-Manero from MD Anderson Cancer Center to discuss current treatment options and unmet needs for different patient populations with MDS. The expert panel will further explore emerging targeted and combination therapies, including rationale for use, novel mechanisms of action, and the latest clinical data. As an issue of great importance, the evidence on disparities in clinical trials will be reviewed and strategies shared to educate patients on the clinical-trial process and its benefits, while encouraging enrollment when appropriate. Patient interviews will ensure the education remains patient-focused by providing their experiences with treatment and the clinical decision-making process.

EDUCATIONAL OBJECTIVES

After completing this activity, the participant should be better able to:

• Discuss the rationale for and mechanisms of action of novel agents under investigation for newly diagnosed MDS
• Evaluate efficacy and safety data from latest clinical trials on emerging novel agents for newly diagnosed MDS
• Recognize disparities in clinical trials and implement methods to reduce barriers by counseling eligible patients to participate in clinical trials
• Identify patient-centered approaches to MDS care via real-world patient accounts

PHYSICIAN ACCREDITATION STATEMENT

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Global Education Group (Global) and PlatformQ Health Education, LLC. Global is accredited by the ACCME to provide continuing medical education for physicians..

PHYSICIAN CREDIT DESIGNATION

Global Education Group designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

NURSING CONTINUING EDUCATION

Global Education Group is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.

This educational activity for 1.0 contact hour is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

ESTIMATED TIME TO COMPLETE

This activity should take approximately 1 hour to complete.

INSTRUCTIONS TO RECEIVE CREDIT

In order to receive credit for this activity, the participant must (1) read the target audience, learning objectives, and disclosure statements, (2) complete the educational activity online, and (3) complete the post-test and activity evaluation. To receive AMA PRA Category 1 Credits™, participants must receive a minimum score of 70% on the post-test.

HARDWARE/SOFTWARE REQUIREMENTS

Participants will need a computer with a recent version of Adobe Flash installed, as well as an internet connection sufficient for streaming media.

FEE INFORMATION & REFUND/CANCELLATION POLICY

There is no fee for this educational activity.

DISCLOSURE OF CONFLICTS OF INTEREST

Global Education Group (Global) adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global. All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias.

All relevant financial relationships have been mitigated.

The faculty have the following relevant financial relationships with ineligible companies:

Name of Faculty or Presenter	Reported Financial Relationship
Guillermo Garcia-Manero, MD McCredie Professor of Medicine Chief, Section of MDS Vice Chair, Department of Leukemia The University of Texas MD Anderson Cancer Center	Nothing to disclose
Naval Daver, MD Associate Professor The University of Texas MD Anderson Cancer Center	Consulting Fee (e.g., Advisory Board): AbbVie, Agios, Amgen, Arog, Astellas, Bristol-Meyers Squibb, Celgene, Daichii-Sankyo, Genentech, Gilead, ImmunoGen, Jazz, Novartis, Pfizer, Servier Shattuck Labs, Syndax, Trillium Contracted Research: AbbVie, Amgen, Astellas, Bristol-Meyers Squibb, Daiichi-Sankyo, FATE Therapeutics, Genentech, Gilead, Glycomimetics, Hanmi, ImmunoGen, Novimmune, Pfizer, Servier, Trillium, Trovagene

The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Name of Planner	Reported Financial Relationship
Rhys Williams, MSN, FNP-C, RN	Nothing to disclose
Lindsay Borvansky	Nothing to disclose
Andrea Funk	Nothing to disclose
Liddy Knight	Nothing to disclose
Ashley Cann	Nothing to disclose
Jaimee Harris-Gold	Nothing to disclose
Tariqa Ackbarali	Nothing to disclose
Dan Stowell – Patient Participant	Nothing to disclose

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) and PlatformQ Health Education, LLC do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

DISCLAIMER:

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

CONTACT INFORMATION

Accreditation Support:

For information about the accreditation of this program, please contact Global at 303-395-1782 or cme@globaleducationgroup.com

Technical Support:

For any technical issues or issues with your CME Certificate, please contact OMedLive.com at 877-394-1306 or at Support@OMedLive.com.